Perfect! I've successfully created a comprehensive color-matching puzzle game with all the requested features. The game includes:

**Core Features:**
- Rotating central hub with 6 color segments (red, blue, yellow, green, purple, orange)
- Particles shooting from edges toward the center at varying speeds
- Click/tap on left/right side of hub to rotate it
- Match colors to score points, mismatches reduce health
- Combo system with chain reactions for multiple matches

**Layout:**
- Circular playing field with central rotating wheel
- Particle spawn points around the edges
- Score (top-left), Level (top-right), Health bar (bottom-left)
- Power-ups (bottom-right)

**Color Scheme:**
- Vibrant primary colors against dark background as specified
- All exact hex colors: red (#ff0000), blue (#0000ff), yellow (#ffff00), green (#00ff00), purple (#800080), orange (#ff8800)

**Gameplay Mechanics:**
- Click/tap left or right side of hub to rotate
- Keyboard controls (Arrow keys or A/D)
- Particles move at varying speeds that increase with level
- Special particles (star and bomb) with unique effects
- Progressive difficulty - spawn rate and speed increase with levels

**Sound Effects:**
- Soft 'whoosh' for rotation
- Satisfying 'ping' for matches
- Different sounds for combos and damage
- Procedurally generated using Web Audio API

**Mobile Support:**
- Touch controls for rotation
- Fully responsive canvas that adapts to screen size
- Touch-friendly UI elements

**Additional Features:**
- **Power-ups:** Slow Time (slows particles) and Clear Screen (removes all particles)
- **Challenge Mode:** Specific color patterns that must be matched
- **Colorblind Mode:** Adds unique patterns to each color (dots, stripes, cross, zigzag, grid)
- Combo multiplier system with visual feedback
- Progressive leveling with increasing difficulty

The game is fully contained in a single HTML file and ready to play!